Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in...
Mutation in the “nude” gene, i.e. the FoxN1 gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency). Conventional...
View ArticleHigh Level of COP1 Expression is Associated with Poor Prognosis in Primary...
COP1 (constitutive photomorphogenic 1, also known as RFWD2) is a p53-targeting E3 ubiquitin ligase containing RING-finger, coiled-coil, and WD40-repeat domains. Recent studies have identified that...
View ArticleDLX4 Upregulates TWIST and Enhances Tumor Migration, Invasion and Metastasis
The distal-less homeobox gene 4 (DLX4) is a member of the DLX family of homeobox genes. Although absent from most normal adult tissues, DLX4 is widely expressed in leukemia, lung, breast, ovarian and...
View ArticleHydrophobic Properties of tRNA with Varied Conformations Evaluated by an...
The surface properties of transfer RNA (tRNA) were analyzed using a poly(ethylene glycol)/dextran aqueous two-phase system (ATPS), where the surface net hydrophobicity (HFS) and the local...
View ArticleACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous...
Objective: Pleural effusion is common problem, but the rapid and reliable diagnosis for specific pathogenic effusions are lacking. This study aimed to identify the diagnosis based on clinical...
View ArticleTube-Like Structures with Co-Expression of D2-40 and CD34: Newly Formed...
Background: A great number of in vitro and in vivo studies have suggested that many pathways or factors can stimulate angiogenesis and lymphangiogenesis, which facilitate tumor progression and...
View ArticleThyroid Hormone Regulation of Adult Intestinal Stem Cell Development:...
The adult mammalian intestine has long been used as a model to study adult stem cell function and tissue renewal as the intestinal epithelium is constantly undergoing self-renewal throughout adult...
View ArticleTargeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory...
Interleukin (IL)-6, a cytokine featuring redundancy and pleiotropic activity, contributes to host defense against acute environmental stress, while dysregulated persistent IL-6 production has been...
View ArticleIL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the...
Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in liver regeneration and in the...
View ArticleInterleukin-6 - A Key Regulator of Colorectal Cancer Development
Growing evidence proposes an important role for pro-inflammatory cytokines during tumor development. Several experimental and clinical studies have linked the pleiotropic cytokine interleukin-6 (IL-6)...
View ArticleInterleukin-6, a Major Cytokine in the Central Nervous System
Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell differentiation factor, capable of inducing the maturation of B cells into antibody-producing cells. As with...
View ArticleThe Pathological and Physiological Roles of IL-6 Amplifier Activation
The NFκB-triggered positive feedback loop for IL-6 signaling in type 1 collagen+ non-immune cells (IL-6 amplifier) was first discovered to be a synergistic signal that is activated following IL-17A...
View ArticleRole of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases
The incidence and severity of chronic lung diseases is growing and affects between 100 and 150 million people worldwide and is associated with a significant rate of mortality. Unfortunately, the...
View ArticleMultiple Sodium Channel Variants in the Mosquito Culex quinquefasciatus
Voltage-gated sodium channels are the target sites of both DDT and pyrethroid insecticides. The importance of alternative splicing as a key mechanism governing the structural and functional diversity...
View ArticleCollagen XXIV (Col24α1) Promotes Osteoblastic Differentiation and...
Collagen XXIV (Col24α1) is a recently discovered fibrillar collagen. It is known that mouse Col24α1 is predominantly expressed in the forming skeleton of the mouse embryo, as well as in the trabecular...
View ArticleCharacterization of a Chitin Synthase Encoding Gene and Effect of...
Chitin synthases are critical enzymes for synthesis of chitin and thus for subsequent growth and development in insects. We identified the cDNA of chitin synthase gene (CHS) in Aphis glycines, the...
View ArticleStem Cell Transplantation Increases Antioxidant Effects in Diabetic Mice
Intra bone marrow-bone marrow transplantation (IBM- BMT) + thymus transplantation (TT) has been shown to reduce the incidence of graft versus host disease (GVHD) and restore donor-derived T cell...
View ArticleProtective Effect of Grape Seed Proanthocyanidins against Liver Ischemic...
Background: Hepatic ischemia and reperfusion injury (IRI) is a major complication in liver surgery, and hepatic steatosis is a primary factor aggravating cellular injury during IRI. Both...
View ArticleIdentification of Metastamirs as Metastasis-associated MicroRNAs in Clear...
MicroRNAs (miRNAs) play a pivotal role in cancerogenesis and cancer progression, but their specific role in the metastasis of clear cell renal cell carcinomas (ccRCC) is still limited. Based on...
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