Differentially Expressed Genes Distributed Over Chromosomes and Implicated in...
Release of genetically modified (GM) plants has sparked off intensive debates worldwide partly because of concerns about potential adverse unintended effects of GM plants to the agro system and the...
View ArticleComplexities of TGF-β Targeted Cancer Therapy
Many advanced tumors produce excessive amounts of Transforming Growth Factor-β (TGF-β) which, in normal epithelial cells, is a potent growth inhibitor. However, in oncogenically activated cells, the...
View ArticleStructural and Functional Difference of Pheromone Binding Proteins in...
Pheromone-binding proteins (PBPs) of the gypsy moth, Lymantria dispar L., play an important role in olfaction. Here structures of PBPs were first built by Homology Modeling, and each model of PBPs had...
View ArticleCD133+EpCAM+ Phenotype Possesses More Characteristics of Tumor Initiating...
Background: EpCAM or CD133 has been used as the tumor initiating cells (TICs) marker in hepatocellular carcinoma (HCC). We investigated whether cells expressing with both EpCAM and CD133 surface...
View ArticlePreservation of Fertility in Females Treated for Cancer
Advancements of diagnosis and treatment have substantially improved cancer survival rates in the last few decades. The increasing number of survivors focuses attention on long-term effects caused by...
View ArticleMicroRNA Expression Profile in RAW264.7 cells in Response to Brucella...
MicroRNA (miRNA) is small non-coding RNA with approximate 22 nt in length. Recent studies indicate that miRNAs play significant roles in pathogen-host interactions. Brucella organisms are...
View ArticleMolecular Dynamics Simulation and Bioinformatics Study on Yeast Aquaporin...
In the present study, an equilibrated system for the Aqy1 tetramer was developed, and molecular biophysics modeling showed that the Aqy1 channel was blocked by Tyr-31 in the N-terminus, which was also...
View ArticleCandidate chemosensory Genes in Female Antennae of the Noctuid Moth...
Chemical senses are crucial for all organisms to detect various environmental information. Different protein families, expressed in chemosensory organs, are involved in the detection of this...
View ArticleProtein Interactions on Telomeric Retrotransposons in Drosophila
Telomere length in Drosophila is maintained by targeted transposition of three non-LTR retrotransposons: HeT-A, TART and TAHRE (HTT), but understanding the regulation of this process is hindered by...
View ArticleTGF-β-Operated Growth Inhibition and Translineage Commitment into Smooth...
The periodontal ligament (PDL) is a fibrous connective tissue that attaches the tooth to the alveolar bone. We previously demonstrated the ability of PDL fibroblast-like cells to construct an...
View ArticleReduced Activity of Protein Kinase C in the Frontal Cortex of Subjects with...
Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein...
View ArticleMolecular and Biochemical Characterization of a Novel...
Insect β-N-acetyl-D-hexosaminidases with broad substrate-spectrum (IBS-Hex) are the homologues of human β-N-acetyl-D-hexosaminidase A/B (HsHex A/ B). These enzymes are distributed in most insect...
View ArticleMolecular Characterization of an Ice Nucleation Protein Variant (InaQ) from...
The ice nucleation protein (INP) of Pseudomonas syringae has gained scientific interest not only because of its pathogenicity of foliar necroses but also for its wide range of potential applications,...
View ArticleInterferon-Gamma-Induced Nitric Oxide Inhibits the Proliferation of Murine...
Renal cell carcinoma (RCC) remains one of the most resistant tumors to systemic chemotherapy, radiotherapy, and immunotherapy. Despite great progress in understanding the basic biology of RCC, the...
View ArticleWhy Would Plant Species Become Extinct Locally If Growing Conditions Improve?
Two assumptions underlie current models of the geographical ranges of perennial plant species: 1. current ranges are in equilibrium with the prevailing climate, and 2. changes are attributable to...
View ArticleFOXC1 Contributes To Microvascular Invasion In Primary Hepatocellular...
The existence of microvascular invasion (MVI) formation is one of the most important risk factors predicting poor outcome in hepatocellular carcinoma (HCC) and its mechanism remains largely unknown....
View ArticleTissue-Specific Transcriptome Profiling of Plutella Xylostella Third Instar...
The larval midgut of diamondback moth, Plutella xylostella, is a dynamic tissue that interfaces with a diverse array of physiological and toxicological processes, including nutrient digestion and...
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