The Pro-inflammatory Role of TGFβ1: A Paradox?
TGFβ1 was initially identified as a potent chemotactic cytokine to initiate inflammation, but the autoimmune phenotype seen in TGFβ1 knockout mice reversed the dogma of TGFβ1 being a pro-inflammatory...
View ArticleSimvastatin Modulates Remodeling of Kv4.3 Expression in Rat Hypertrophied...
Objectives: Hypertrophy has been shown to be associated with arrhythmias which can be caused by abnormal remodeling of the Kv4-family of transient potassium channels. Inhibitors of...
View ArticleInterleukin-22 Ameliorates Cerulein-Induced Pancreatitis in Mice by...
Pancreatitis occurs when digestive enzymes are activated in the pancreas. Severe pancreatitis has a 10-30% mortality rate. No specific treatments for pancreatitis exist now. Here, we discovered that...
View ArticleAn Updated Nomenclature for Keratin-Associated Proteins (KAPs)
Most protein in hair and wool is of two broad types: keratin intermediate filament-forming proteins (commonly known as keratins) and keratin-associated proteins (KAPs). Keratin nomenclature was...
View ArticleMeasurement of Hepatic Protein Fractional Synthetic Rate with Stable Isotope...
Severe burn-induced liver damage and dysfunction is associated with endoplasmic reticulum (ER) stress. ER stress has been shown to regulate global protein synthesis. In the current study, we induced...
View ArticleTGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in a vast majority of cellular processes and is fundamentally important throughout life. TGF-β/BMPs have...
View ArticleActivated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like...
Neuroblastoma is an embryonic malignancy arising from neuroblasts. The mechanisms that regulate the origination of neuroblastoma are still not very clear. In this study, we revealed that...
View ArticlePretreatment of Cisplatin in Recipients Attenuates Post-Transplantation...
Pancreas transplantation is the definite treatment for type 1 diabetes that enables the achievement of long-term normoglycemia and insulin independence. However Post-Transplantation Pancreatitis (PTP)...
View ArticleAn Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar...
View ArticleGene Expression Profiling of the Cephalothorax and Eyestalk in Penaeus...
In crustaceans, a range of physiological processes involved in ovarian maturation occurs in organs of the cephalothorax including the hepatopancrease, mandibular and Y-organ. Additionally,...
View ArticleU12-type Spliceosomal Introns of Insecta
Most of eukaryotic genes are interrupted by introns that need to be removed from pre-mRNAs before they can perform their function. This is done by complex machinery called spliceosome. Many eukaryotes...
View ArticleComparison of Protein Expression Profiles of Different Stages of Lymph Nodes...
Breast cancer is the most common cancer among women worldwide. Breast cancer metastasis primarily happens through lymphatic system, where the extent of lymph node metastasis is the major factor...
View ArticleProtective Effects of Garlic Oil on Hepatocarcinoma Induced by...
To investigate the protective effects and the possible mechanisms of garlic oil (GO) against N-nitrosodiethylamine (NDEA)-induced hepatocarcinoma in rats, Wistar rats were gavaged with GO (20 or 40...
View ArticlePolymorphic Allele of Human MRC1 Confer Protection against Tuberculosis in a...
Mannose receptor is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition, and plays a critical role in shaping host immune response. Single nucleotide...
View ArticleInterleukin-11 Promotes the Progress of Gastric Carcinoma via Abnormally...
Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines. The aberrant expression of versican...
View ArticleSwainsonine Activates Mitochondria-mediated Apoptotic Pathway in Human Lung...
Swainsonine (1, 2, 8-trihyroxyindolizidine, SW), a natural alkaloid, has been reported to exhibit anti-cancer activity on several mouse models of human cancer and human cancers in vivo. However, the...
View ArticlePhenotypic Characterization of Osteoarthritic Osteocytes from the Sclerotic...
Subchondral bone sclerosis is a well-recognised manifestation of osteoarthritis (OA). The osteocyte cell network is now considered to be central to the regulation of bone homeostasis; however, it is...
View ArticleIsolation and Identification of miRNAs in Jatropha curcas
MicroRNAs (miRNAs) are small noncoding RNAs that play crucial regulatory roles by targeting mRNAs for silencing. To identify miRNAs in Jatropha curcas L, a bioenergy crop, cDNA clones from two small...
View ArticleHydrogen Sulfide Mitigates Cardiac Remodeling During Myocardial Infarction...
Exogenous hydrogen sulfide (H2S) leads to down-regulation of inflammatory responses and provides myocardial protection during acute ischemia/reperfusion injury; however its role during chronic heart...
View ArticlePrognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy
Filamin-A, also called Actin Binding Protein-280, is not only an essential component of the cytoskeleton networks, but also serves as the scaffold in various signaling networks. It has been shown that...
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