The Silencing of RECK Gene is Associated with Promoter Hypermethylation and...
Background: To evaluate the promoter methylation status of RECK gene and mRNA expression in patients with hepatocellular carcinoma (HCC).Methods: We analyzed RECK methylation by MSP, and RECK mRNA by...
View ArticleOLFML3 Expression is Decreased during Prenatal Muscle Development and...
The Olfactomedin-like 3 (OLFML3) gene has matrix-related function involved in embryonic development. MicroRNA-155 (miR-155), 21- to 23-nucleotides (nt) noncoding RNA, regulated myogenesis by target...
View ArticleThe Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
In 1995, the steroid receptor coactivator-1 (SRC-1) was identified as the first authentic steroid receptor coactivator. Since then, the SRC proteins have remained at the epicenter of coregulator...
View ArticleA Comparative Study of Mammalian Diversification Pattern
Although mammals have long been regarded as a successful radiation, the diversification pattern among the clades is still poorly known. Higher-level phylogenies are conflicting and comprehensive...
View ArticleCharacterization of Bovine Induced Pluripotent Stem Cells by Lentiviral...
Pluripotent stem cells from domesticated animals have potential applications in transgenic breeding. Here, we describe induced pluripotent stem (iPS) cells derived from bovine fetal fibroblasts by...
View ArticlePropolis Standardized Extract (EPP-AF®), an Innovative Chemically and...
The aim of this study was to develop a formulation, containing the propolis standardized extract (EPP-AF®), which can assist in the healing of skin lesions. To achieve this objective the antimicrobial...
View ArticleTWIST Represses Estrogen Receptor-alpha Expression by Recruiting the NuRD...
Loss of estrogen receptor α (ERα) expression and gain of TWIST (TWIST1) expression in breast tumors correlate with increased disease recurrence and metastasis and poor disease-free survival. However,...
View ArticleIsoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in...
Isoalantolactone, a sesquiterpene lactone compound possesses antifungal, antibacteria, antihelminthic and antiproliferative activities. In the present study, we found that isoalantolactone inhibits...
View ArticleData Mining in Networks of Differentially Expressed Genes during Sow Pregnancy
Small to moderate gains in Pig fertility can mean large returns in overall efficiency, and developing methods to improve it is highly desirable. High fertility rates depend on completion of successful...
View ArticleCharacterization of the Complete Mitochondrial Genomes of Cnaphalocrocis...
The complete mitochondrial genomes (mitogenomes) of Cnaphalocrocis medinalis and Chilo suppressalis (Lepidoptera: Pyralidae) were determined and analyzed. The circular genomes were 15,388 bp long for...
View ArticleGenome-Wide Association Analysis of Meat Quality Traits in a Porcine Large...
Pork quality is an economically important trait and one of the main selection criteria for breeding in the swine industry. In this genome-wide association study (GWAS), 455 pigs from a porcine Large...
View ArticleThe Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by...
The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53N236S (p53N239S in human, p53S)...
View ArticleDrosophila eyes absent is a Novel mRNA Target of the Tristetraprolin (TTP)...
The Tristetraprolin (TTP) protein family includes four mammalian members (TTP, TIS11b, TIS11d, and ZFP36L3), but only one in Drosophila melanogaster (DTIS11). These proteins bind target mRNAs with...
View ArticleReal-time Investigation of Measles Epidemics with Estimate of Vaccine Efficacy
As part of measles elimination effort, evaluation of the vaccination program and real-time assessment of the epidemic dynamics constitute two important tasks to improve and strengthen the control. The...
View ArticleGlycosylation of the Sodium Channel β4 Subunit is Developmentally Regulated...
Aberrant protein glycosylation plays major roles in neurodegenerative diseases, including Parkinson's disease (PD). Glycoproteomics showed that the glycosylation of sodium channel β4 was significantly...
View ArticleCharacterization of the Complete Mitochondrial Genome Sequence of Spirometra...
Sparganosis, caused by the plerocercoid larvae of members of the genus Spirometra, can cause significant public health problem and considerable economic losses. In the present study, the complete...
View ArticleSelection of Peptide Inhibitor to Matrix Metalloproteinase-2 Using Phage...
Despite tremendous advances in cancer treatment and survival rates, pancreatic cancer remains one of the most deadly afflictions and the fourth leading cause of cancer deaths in the world. Matrix...
View ArticleFibroblast Growth Factor-23 Helps Explain the Biphasic Cardiovascular Effects...
Hypovitaminosis D is highly prevalent in chronic kidney disease (CKD). Recently, vitamin D has sparked widespread interest because of its potential favorable benefits on cardiovascular disease (CVD)....
View ArticleSurf the Post-translational Modification Network of p53 Regulation
Among the human genome, p53 is one of the first tumor suppressor genes to be discovered. It has a wide range of functions covering cell cycle control, apoptosis, genome integrity maintenance,...
View ArticleInteractions of Several Lipid-Related Gene Polymorphisms and Cigarette...
The interactions of single nucleotide polymorphisms (SNPs) and cigarette smoking on blood pressure levels are limited. The present study was undertaken to detect nine lipid-related SNPs and their...
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