Enhanced Antitumor Efficacy of Gemcitabine by Evodiamine on Pancreatic Cancer...
Evodiamine has therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and evodiamine enhanced antitumor efficacy in pancreatic...
View ArticleInfluence of Five Potential Anticancer Drugs on Wnt Pathway and Cell Survival...
Background: The role of Wnt signalling in carcinogenesis suggests compounds targeting this pathway as potential anti-cancer drugs. Several studies report activation of Wnt signalling in biliary tract...
View ArticleSerum Bone Alkaline Phosphatase in Assessing Illness Severity of Infected...
Background: Infections can influence bone metabolism of neonates, which may lead to changes in some bone metabolism biomarkers. The purpose of this study was to determine whether serum bone alkaline...
View ArticleTwo Closely Related Human Members of Chitinase-like Family, CHI3L1 and...
The activation of extracellular signal-regulated kinases (ERK1/2) has been associated with specific outcomes. Sustained activation of ERK1/2 by nerve growth factor (NGF) is associated with...
View ArticleLocalization, Expression Change in PRRSV Infection and Association Analysis...
The transporter associated with antigen processing (TAP) translocates antigenic peptides from the cytosol into the lumen of the endoplasmic reticular and plays a critical role in the major...
View ArticleEZH2 Methyltransferase and H3K27 Methylation in Breast Cancer
Histone modifications are thought to control the regulation of genetic programs in normal physiology and cancer. Methylation (mono-, di-, and tri-methylation) on histone H3 lysine (K) 27 induces...
View ArticleProteomic Analysis on Acetate Metabolism in Citrobacter sp. BL-4
Mass production of glucosamine (GlcN) using microbial cells is a worthy approach to increase added values and keep safety problems in GlcN production process. Prior to set up a microbial cellular...
View ArticleThe Putative Metal Coordination Motif in the Endonuclease Domain of Human...
The non-structural proteins (NS) of the parvovirus family are highly conserved multi-functional molecules that have been extensively characterized and shown to be integral to viral replication. Along...
View ArticleThe Complete Mitochondrial Genome of the Damsel Bug Alloeorhynchus bakeri...
The complete sequence of the mitochondrial DNA (mtDNA) of the damsel bug, Alloeorhynchus bakeri, has been completed and annotated in this study. It represents the first sequenced mitochondrial genome...
View ArticleIdentification of Ghrelin Receptor Blocker, D-[Lys3] GHRP-6 as a CXCR4...
[D-Lys3]-Growth Hormone Releasing Peptide-6 (DLS) is widely utilized in vivo and in vitro as a selective ghrelin receptor (GHS-R) antagonist. Unexpectedly, we identified that DLS also has the ability...
View ArticleImmune-related MicroRNAs are Abundant in Breast Milk Exosomes
Breast milk is a complex liquid rich in immunological components that affect the development of the infant's immune system. Exosomes are membranous vesicles of endocytic origin that are found in...
View ArticleMolecular Cloning and Characterization of Ecdysone oxidase and...
Molting hormone (ecdysteroid) is one of the most important hormones in insects. The synthesis and inactivation of the ecdysteroid regulate the developmental process of insects. A major pathway of...
View ArticleAltered Antioxidant Status and Increased Lipid Per-Oxidation in Seminal...
Human seminal plasma is a natural reservoir of antioxidants that protect spermatozoa from oxidative damages. There is evidence in literature supports the fact that impairments in seminal antioxidant...
View ArticleMatrine Inhibits Pacing Induced Atrial Fibrillation by Modulating IKM3 and ICa-L
Aim: To elucidate the protective effects of Matrine on atrial fibrillation (AF) induced by electric pacing in mice and underlying molecular and ion channel mechanisms.Methods: AF was introduced by...
View ArticleThe Olfactory Co-receptor Orco from the Migratory Locust (Locusta migratoria)...
In locusts, olfaction plays a crucial role for initiating and controlling behaviours, including food seeking and aggregation with conspecifics, which underlie the agricultural pest capacity of the...
View ArticleThe Murine Caecal MicroRNA Signature Depends on the Presence of the...
The intestinal messenger RNA expression signature is affected by the presence and composition of the endogenous microbiota, with effects on host physiology. The intestine is also characterized by a...
View ArticleThe Adhesion Modulating Properties of Tenascin-W
Tenascins are extracellular matrix glycoproteins associated with cell motility, proliferation and differentiation. Tenascin-C inhibits cell spreading by binding to fibronectin; tenascin-R and...
View ArticleTGFβ Signaling and Cardiovascular Diseases
Transforming growth factor β (TGFβ) family members are involved in a wide range of diverse functions and play key roles in embryogenesis, development and tissue homeostasis. Perturbation of TGFβ...
View ArticleContrasting Cellularity and Fatty Acid Composition in Fat Depots from...
During the finishing phase of bovines, large amounts of subcutaneous and visceral fats are deposited leading to production inefficiencies with major impact on meat quality. A better understanding of...
View Article